abstract：:The role of dynamic processes on self-assembled structures of 4'-([2,2':6', 2''-terpyridin]-4'-yl)-[1,1'-biphenyl]-4-carboxylic acid (l) molecules on Au(III) has been studied by scanning tunneling microscopy. The as-deposited monolayer is closed-packed and periodic in a short-range due to dipole forces. A thermal anne...

journal_title：International journal of molecular sciences

authors： Liu X,Wang Y,Song X,Chen F,Ouyang H,Zhang X,Cai Y,Liu X,Wang L

更新日期：2013-03-11 00:00:00

abstract：:Transthyretin (TTR) is a homotetrameric protein that circulates in plasma and cerebral spinal fluid (CSF) whose aggregation into amyloid fibrils has been associated with at least two different amyloid diseases: senile systemic amyloidosis (SSA) and familial amyloid polyneuropathy (FAP). In SSA aggregates are composed ...

journal_title：International journal of molecular sciences

authors： Sant'anna RO,Braga CA,Polikarpov I,Ventura S,Lima LM,Foguel D

更新日期：2013-03-06 00:00:00

abstract：:Plant lipid transfer proteins (LTPs) are encoded by multigene families and play important roles in plant physiology. One full-length cDNA encoding an Arabidopsis LTP3 homologue was isolated from maize by RT-PCR and named as ZmLTP3. RT-PCR analysis indicated that the ZmLTP3 expression is induced by salicylic acid (SA),...

journal_title：International journal of molecular sciences

authors： Zou HW,Tian XH,Ma GH,Li ZX

更新日期：2013-03-01 00:00:00

abstract：:Invasive species represent an increasing threat to native ecosystems, harming indigenous taxa through predation, habitat modification, cross-species hybridization and alteration of ecosystem processes. Additionally, high economic costs are associated with environmental damage, restoration and control measures. The Bur...

journal_title：International journal of molecular sciences

authors： Hunter ME,Hart KM

更新日期：2013-02-28 00:00:00

abstract：:It has generally been considered that protein phosphatases have more diverse catalytic domain structures and mechanisms than protein kinases; however, gene annotation efforts following the human genome project appeared to have completed the whole array of protein phosphatases. Ser/Thr phosphatases are divided into thr...

journal_title：International journal of molecular sciences

authors： Sadatomi D,Tanimura S,Ozaki K,Takeda K

更新日期：2013-02-26 00:00:00

abstract：:Apolipoprotein M (apoM) is a plasma apolipoprotein that mainly associates with high-density lipoproteins. Hence, most studies on apoM so far have investigated its effect on and association with lipid metabolism and atherosclerosis. The insight into apoM biology recently took a major turn. ApoM was identified as a carr...

journal_title：International journal of molecular sciences

authors： Arkensteijn BW,Berbée JF,Rensen PC,Nielsen LB,Christoffersen C

更新日期：2013-02-25 00:00:00

abstract：:Nanoencapsulation of thiamine dilauryl sulfate (TDS), a vitamin B1 derivative, was proved to effectively inhibit the spore germination of Fusarium oxysporum f. sp. raphani (F. oxysporum), as well as mycelial growth. The average diameter of nanoparticles was measured as 136 nm by being encapsulated with an edible encap...

journal_title：International journal of molecular sciences

authors： Cho JS,Seo YC,Yim TB,Lee HY

更新日期：2013-02-21 00:00:00

abstract：:This experiment aimed to investigate the effects of the chitosan (CTS) and water-soluble chitosan (WSC) microspheres on plasma lipids in male Sprague-Dawley rats fed with high-fat diets. CTS microspheres and WSC microspheres were prepared by the spray-drying technique. Scanning electron microscopy (SEM) micrographs s...

journal_title：International journal of molecular sciences

authors： Tao Y,Zhang HL,Hu YM,Wan S,Su ZQ

更新日期：2013-02-19 00:00:00

abstract：:A combined theoretical and experimental study on the structure, infrared, UV-Vis and 1H NMR data of trans-2-(m-cyanostyryl)pyridine, trans-2-[3-methyl-(m-cyanostyryl)]pyridine and trans-4-(m-cyanostyryl)pyridine is presented. The synthesis was carried out with an efficient Knoevenagel condensation using green chemist...

journal_title：International journal of molecular sciences

authors： Castro ME,Percino MJ,Chapela VM,Ceron M,Soriano-Moro G,Lopez-Cruz J,Melendez FJ

更新日期：2013-02-18 00:00:00

abstract：:Melatonin is a pleiotropic molecule with many cellular and systemic actions, including chronobiotic effects. Beneficial effects are widely documented concerning the treatment of neoplastic diseases in vivo as well as reductions in viability of cultured cells from melanoma, one of the most aggressive cancers in humans....

journal_title：International journal of molecular sciences

authors： Bonmati-Carrion MA,Alvarez-Sánchez N,Hardeland R,Madrid JA,Rol MA

更新日期：2013-02-14 00:00:00

abstract：:Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methan...

journal_title：International journal of molecular sciences

authors： Lee CW,Ko HH,Chai CY,Chen WT,Lin CC,Yen FL

更新日期：2013-02-12 00:00:00

abstract：:Akirin is a recently discovered nuclear factor that plays an important role in innate immune responses. Beyond its role in innate immune responses, Akirin has recently been shown to play an important role in skeletal myogenesis. In this article, we will briefly review the structure and tissue distribution of Akirin an...

journal_title：International journal of molecular sciences

authors： Chen X,Huang Z,Wang H,Jia G,Liu G,Guo X,Tang R,Long D

更新日期：2013-02-08 00:00:00

abstract：:Extracellular-signal regulated kinase (ERK) signaling is required for a multitude of physiological and patho-physiological processes. However, the identities of the proteins that ERK phosphorylates to elicit these responses are incompletely known. Using an affinity purification methodology of general utility, here we ...

journal_title：International journal of molecular sciences

authors： Pullikuth AK,Ozdemir A,Cardenas D,Bailey E,Sherman NE,Pfister KK,Catling AD

更新日期：2013-02-07 00:00:00

abstract：:Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which ...

journal_title：International journal of molecular sciences

authors： Ndjonka D,Rapado LN,Silber AM,Liebau E,Wrenger C

更新日期：2013-02-06 00:00:00

abstract：:p-Sulfonatocalixarenes are a special class of water soluble macrocyclic molecules made of 4-hydroxybenzenesulfonate units linked by methylene bridges. One of the main features of these compounds relies on their ability to form inclusion complexes with cationic and neutral species. This feature, together with their wat...

journal_title：International journal of molecular sciences

authors： Basilio N,Francisco V,Garcia-Rio L

更新日期：2013-02-04 00:00:00

abstract：:The enzymatic condition for producing the anti-obesity hydrolysates from fish water-soluble protein was optimized with the aid of response surface methodology, which also derived a statistical model for experimental validation. Compared with neutral protease, papain and protamex, the porcine pancreas lipase inhibitory...

journal_title：International journal of molecular sciences

authors： Liu L,Wang Y,Peng C,Wang J

更新日期：2013-02-01 00:00:00

abstract：:The role of the collagen-platelet interaction is of crucial importance to the haemostatic response during both injury and pathogenesis of the blood vessel wall. Of particular interest is the high affinity interaction of the platelet transmembrane receptor, alpha 2 beta 1, responsible for firm attachment of platelets t...

journal_title：International journal of molecular sciences

authors： Attwood SJ,Simpson AM,Hamaia SW,Bihan D,Roy D,Farndale RW,Welland ME

更新日期：2013-01-29 00:00:00

abstract：:Electronegative low-density lipoprotein (LDL(-)) is a minor modified LDL subfraction that is present in blood. LDL(-) promotes inflammation and is associated with the development of atherosclerosis. We previously reported that the increase of cytokine release promoted by this lipoprotein subfraction in monocytes is co...

journal_title：International journal of molecular sciences

authors： Estruch M,Sanchez-Quesada JL,Beloki L,Ordoñez-Llanos J,Benitez S

更新日期：2013-01-28 00:00:00

abstract：:To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments ...

journal_title：International journal of molecular sciences

authors： Cardinali DP,Bernasconi PA,Reynoso R,Toso CF,Scacchi P

更新日期：2013-01-25 00:00:00

abstract：:Brain metastases (BM) from colorectal cancer (CRC) are a rare but increasing event. Surgical resection of oligometastatic disease, including BM, may produce a survival benefit in selected patients. Previous studies described the HER-2 expression patterns in CRC patients, but its prognostic role still remains controver...

journal_title：International journal of molecular sciences

authors： Aprile G,De Maglio G,Menis J,Casagrande M,Tuniz F,Pisa EF,Fontanella C,Skrap M,Beltrami AC,Fasola G,Pizzolitto S

更新日期：2013-01-24 00:00:00

abstract：:Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding of the tumor metabolism might help us meet the challenges in controlling brain metastases. The study aims to characterize the metabolic profile of brain metastases of di...

journal_title：International journal of molecular sciences

authors： Sjøbakk TE,Vettukattil R,Gulati M,Gulati S,Lundgren S,Gribbestad IS,Torp SH,Bathen TF

更新日期：2013-01-22 00:00:00

abstract：:A simple and reliable method of high-performance liquid chromatography with photodiode array detection (HPLC-DAD) was developed to evaluate the quality of Receptaculum Nelumbinis (dried receptacle of Nelumbo nucifera) through establishing chromatographic fingerprint and simultaneous determination of five flavonol ...

journal_title：International journal of molecular sciences

authors： Wu YB,Zheng LJ,Yi J,Wu JG,Chen TQ,Wu JZ

更新日期：2013-01-21 00:00:00

abstract：:Polymer supported dichlorophosphate (PEG-OPOCl(2)) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their an...

journal_title：International journal of molecular sciences

authors： Naidu KR,Khalivulla SI,Rasheed S,Fakurazi S,Arulselvan P,Lasekan O,Abas F

更新日期：2013-01-16 00:00:00

abstract：:From the stems of Liriodendron tulipifera, seventeen known compounds have been extracted, isolated and purified. By using spectroscopic analysis, the structures of these pure constituents were determined as three lignans, four steroids and ten benzenoids. Identified compounds were screened for antioxidant abilities u...

journal_title：International journal of molecular sciences

authors： Li WJ,Lin YC,Wu PF,Wen ZH,Liu PL,Chen CY,Wang HM

更新日期：2013-01-15 00:00:00

abstract：:There has been a great interest in application of nanoparticles as biomaterials for delivery of therapeutic molecules such as drugs and genes, and for tissue engineering. In particular, biopolymers are suitable materials as nanoparticles for clinical application due to their versatile traits, including biocompatibilit...

journal_title：International journal of molecular sciences

authors： Nitta SK,Numata K

更新日期：2013-01-14 00:00:00

abstract：:Buckwheat sprouts contain various bioactive compounds including rutin which have a number of biological activities. We have previously shown that buckwheat sprouts (TBWE) treated with methyl jasmonate (MeJA) significantly increased the amount of phenolics and the antioxidant activity. The aim of this study was to demo...

journal_title：International journal of molecular sciences

authors： Lee YJ,Kim KJ,Park KJ,Yoon BR,Lim JH,Lee OH

更新日期：2013-01-11 00:00:00

abstract：:Enzymes found in nature have been exploited in industry due to their inherent catalytic properties in complex chemical processes under mild experimental and environmental conditions. The desired industrial goal is often difficult to achieve using the native form of the enzyme. Recent developments in protein engineeri...

journal_title：International journal of molecular sciences

authors： Singh RK,Tiwari MK,Singh R,Lee JK

更新日期：2013-01-10 00:00:00

abstract：:The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtain...

journal_title：International journal of molecular sciences

authors： Rosengren AM,Karlsson BC,Nicholls IA

更新日期：2013-01-09 00:00:00

abstract：:Understanding the composition and structure of the acquired enamel pellicle (AEP) has been a major goal in oral biology. Our lab has conducted studies on the composition of AEP formed on permanent enamel. The exhaustive exploration has provided a comprehensive identification of more than 100 proteins from AEP formed o...

journal_title：International journal of molecular sciences

authors： Zimmerman JN,Custodio W,Hatibovic-Kofman S,Lee YH,Xiao Y,Siqueira WL

更新日期：2013-01-07 00:00:00

abstract：:Fluorescent silica nanoparticles (FSNPs) can provide high-intensity and photostable fluorescent signals as a probe for biomedical analysis. In this study, FSNPs hybridized with aggregation-induced emission (AIE) luminogens (namely FSNP-SD) were successfully fabricated by a surfactant-free sol-gel method. The FSNP-SD w...

journal_title：International journal of molecular sciences

authors： Xia Y,Li M,Peng T,Zhang W,Xiong J,Hu Q,Song Z,Zheng Q

更新日期：2013-01-07 00:00:00

abstract：:The voltage-dependent anion channel (VDAC), a highly conserved major mitochondrial outer membrane protein, plays crucial roles in energy metabolism and metabolite transport. However, knowledge about the roles of the VDAC family in plants is limited. In this study, we investigated the expression pattern of VDAC1 in Ara...

journal_title：International journal of molecular sciences

authors： Li ZY,Xu ZS,He GY,Yang GX,Chen M,Li LC,Ma Y

更新日期：2013-01-04 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating neurological disease that predominantly affects young adults resulting in severe personal and economic impact. The majority of therapies for this disease were developed in, or are beneficial in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. While known...

journal_title：International journal of molecular sciences

authors： Mohammad MG,Hassanpour M,Tsai VW,Li H,Ruitenberg MJ,Booth DW,Serrats J,Hart PH,Symonds GP,Sawchenko PE,Breit SN,Brown DA

更新日期：2012-12-27 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the promotion and progression of cancer, including triple negative breast cancer cells. Thus, there is significant interest in understanding the molecular signaling pathways that connect TNF-α with the survival of tumor cells. In our experi...

journal_title：International journal of molecular sciences

authors： Pileczki V,Braicu C,Gherman CD,Berindan-Neagoe I

更新日期：2012-12-24 00:00:00

abstract：:Fibrotic diseases, such as liver, pulmonary and renal fibrosis, are common end-stage conditions and represent a major global health problem. Furthermore, effective therapeutic measures are presently unavailable. Extracellular matrix accumulation is the most prominent characteristic in the pathogenesis of fibrotic dise...

journal_title：International journal of molecular sciences

authors： Zhou TB,Drummen GP,Qin YH

更新日期：2012-12-21 00:00:00

abstract：:Oenothein B is a unique macrocyclic ellagitannin dimer that has been found in various medicinal plants belonging to Onagraceae, Lythraceae, and Myrtaceae, with diverse biological activities. The immunological effects of tannins in terms of cytokine-release from macrophages and monocytes have been discussed, while the ...

journal_title：International journal of molecular sciences

authors： Yoshimura M,Akiyama H,Kondo K,Sakata K,Matsuoka H,Amakura Y,Teshima R,Yoshida T

更新日期：2012-12-20 00:00:00

abstract：:Plant regeneration and somatic embryogenesis through interspecific hybridization among different Carica species were studied for the development of a papaya ringspot virus-resistant variety. The maximum fruit sets were recorded from the cross of the native variety C. papaya cv. Shahi with the wild species C. cauliflor...

journal_title：International journal of molecular sciences

authors： Azad MA,Rabbani MG,Amin L

更新日期：2012-12-12 00:00:00

abstract：:The protective effect of sesamin (SES) from sesame meal on NIT-1 pancreatic β-cells damaged by streptozotocin (STZ) in vitro was investigated. The cell viability, insulin secretion, the activity of superoxide dismutase(SOD), glutathione peroxidase (GSHpx) and the content of reduced glutathione (GSH) increased signific...

journal_title：International journal of molecular sciences

authors： Lei H,Han J,Wang Q,Guo S,Sun H,Zhang X

更新日期：2012-12-11 00:00:00

abstract：:Statistical studies have demonstrated that various agents may reduce the risk of cancer's development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)(GS-OX1), FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last de...

journal_title：International journal of molecular sciences

authors： Wojcieszyńska D,Hupert-Kocurek K,Guzik U

更新日期：2012-12-07 00:00:00

abstract：:The domestic ferret (Mustela putorius furo) is an important model organism for the study of avian influenza and other diseases of humans and animals, as well as a popular pet animal. In order to evaluate genetic diversity and study disease relationships in ferrets, 22 nuclear microsatellite loci (17 dinucleotide and 5...

journal_title：International journal of molecular sciences

authors： Ernest HB,Drazenovich TL,Dalbeck LS,Hawkins MG

更新日期：2012-12-05 00:00:00

abstract：:In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found t...

journal_title：International journal of molecular sciences

authors： Liu JF,Huang YL,Yang WH,Chang CS,Tang CH

更新日期：2012-12-04 00:00:00